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Selectivity of 4j within the human kinome. (A) <t>kinase</t> selectivity profile of compound 4j at 1 uM, evaluated at the <t>Eurofins</t> kinase screening <t>platform,</t> tested against 366 kinases. Moderate: 50%–100%; Weak: > 100%. (B) The 13 kinases with the highest inhibition rate.
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Selectivity of 4j within the human kinome. (A) <t>kinase</t> selectivity profile of compound 4j at 1 uM, evaluated at the <t>Eurofins</t> kinase screening <t>platform,</t> tested against 366 kinases. Moderate: 50%–100%; Weak: > 100%. (B) The 13 kinases with the highest inhibition rate.
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Selectivity of 4j within the human kinome. (A) <t>kinase</t> selectivity profile of compound 4j at 1 uM, evaluated at the <t>Eurofins</t> kinase screening <t>platform,</t> tested against 366 kinases. Moderate: 50%–100%; Weak: > 100%. (B) The 13 kinases with the highest inhibition rate.
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Selectivity of 4j within the human kinome. (A) <t>kinase</t> selectivity profile of compound 4j at 1 uM, evaluated at the <t>Eurofins</t> kinase screening <t>platform,</t> tested against 366 kinases. Moderate: 50%–100%; Weak: > 100%. (B) The 13 kinases with the highest inhibition rate.
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Selectivity of 4j within the human kinome. (A) <t>kinase</t> selectivity profile of compound 4j at 1 uM, evaluated at the <t>Eurofins</t> kinase screening <t>platform,</t> tested against 366 kinases. Moderate: 50%–100%; Weak: > 100%. (B) The 13 kinases with the highest inhibition rate.
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human phosphokinase array  (R&D Systems)
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Selectivity of 4j within the human kinome. (A) <t>kinase</t> selectivity profile of compound 4j at 1 uM, evaluated at the <t>Eurofins</t> kinase screening <t>platform,</t> tested against 366 kinases. Moderate: 50%–100%; Weak: > 100%. (B) The 13 kinases with the highest inhibition rate.
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Selectivity of 4j within the human kinome. (A) kinase selectivity profile of compound 4j at 1 uM, evaluated at the Eurofins kinase screening platform, tested against 366 kinases. Moderate: 50%–100%; Weak: > 100%. (B) The 13 kinases with the highest inhibition rate.

Journal: ACS Omega

Article Title: Structure-Based Drug Discovery of Triazine Derivatives as Potent and Orally Bioavailable AXL Inhibitors for Cancer Therapy

doi: 10.1021/acsomega.6c04179

Figure Lengend Snippet: Selectivity of 4j within the human kinome. (A) kinase selectivity profile of compound 4j at 1 uM, evaluated at the Eurofins kinase screening platform, tested against 366 kinases. Moderate: 50%–100%; Weak: > 100%. (B) The 13 kinases with the highest inhibition rate.

Article Snippet: The kinase selectivity of compound 4j was assessed at a screening concentration of 1 μM against a panel of 60 human kinases using the Eurofins Kinase Profiler platform.

Techniques: Inhibition